The Immunobiology program consists of five major areas, namely, (1) analysis of disease-associated or therapy-induced immunodeficiency states, (2) attempts at immunologic reconstitution or immunologic modulation as a means of treating immunodeficiency or cancer, (3) exploitation of advances in immunogenetics for the selection of bone marrow donors and for the definition of genetically determined susceptibility to disease, (4) investigation of antibody-mediated and cell-mediated immuno reactions to human cancer antigens, and (5) development of immunologic methods as diagnostic aids. The clinical research program is closely interrelated with an extensive laboratory program in basic immunobiology.